Thrombosis Research
Volume 118, Issue 4 , Pages 505-507 , 2006

The value of St14 (DXS52) VNTR analysis for genetic diagnosis of hemophilia A in Iranian population

  • S. Babak Azimifar

      Affiliations

    • Department of Biology, Faculty of Sciences, Shahid Beheshti University, Shahid Chamran Highway, Evin, Tehran, Iran
    • Corresponding Author InformationCorresponding author. Tel./fax: +98 21 443 9120.
    • ,
  • S. Yoosef Seyedna

      Affiliations

    • Department of Biology, Faculty of Sciences, Shahid Beheshti University, Shahid Chamran Highway, Evin, Tehran, Iran
    • ,
  • Sirous Zeinali

      Affiliations

    • Biotechnology Research Centre, Pasteur Institute of Iran, Tehran, Iran

Received 27 June 2005 ,Revised 9 September 2005 ,Accepted 19 October 2005.

References 

  1. Gitschier J, Goralka TM, Wion KL, Chen EY, Eaton DE, Vehar GA, et al. Characterization of the human factor VIII gene. Nature. 1984;312:326
  2. Peake I. Registry of DNA polymorphisms within or close to the human factor VIII and factor IX genes. For the factor VIII subcommittee of the scientific and standardization committee of the international society on thrombosis and haemostasis. Thromb Haemost. 1992;67:277–280
  3. Lin SR, Lin SW, Hsu YC, Shen MC. Identification of a new CA dinucleotide repeat in the human factor VIII gene. Br J Haematol. 2000;111:1256–1259
  4. Oberle I, Camerino G, Heilig R, Grunebaum L, Cazenave JP, Crapanzano C, et al. Genetic screening for hemophilia A (classic hemophilia) with a polymorphic DNA probe. N Engl J Med. Mar. 14 1985;312(11):682–686
  5. Richards B, Heilig R, Oberle I, Storjohann L, Horn GT. Rapid PCR analysis of the St14 (DXS52) VNTR. Nucleic Acids Res. 1991;19(8):1944
  6. Srinivasan A, Mukhopadhyay S, Karim Z, Gupta RK, Gupta A, Wadhawan V, et al. Factor VIII gene polymorphisms in North Indian population: a consensus algorithm for carrier analysis of hemophilia A. Clin Chim Acta. Nov 2002;325(1–2):177–181
  7. Wang X, Chu X, Ruan C. St14 (DXS52) VNTR in the Chinese population and its application to genetic diagnosis of haemophilia A. Nouv Rev Fr Hematol. Jan 1995;37(3):183–186
  8. Chunlian J, Changkun L, Jun S, Li J, Wenhan D, Xue Z, et al. Polymorphism distribution of ST14(DXS52) VNTR in normal individuals in northeastern region of China and its application in gene diagnosis of hemophilia A. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. Feb. 10 1998;15(1):31–34
  9. Gallegos RM, Aranda HB, Navarrete CP, Espinoza R, Gomez FS, Aranda DA. Polymorphism distribution of Int13, Int22, and St14 VNTRs in a Mexican population and their application in carrier diagnosis of hemophilia A. Am J Hematol. Sep 2004;77(1):1–6
  10. Barnes WM. PCR amplification of up to 35-kb DNA with high fidelity and high yield from λ bacteriophage templates. PNAS. Mar 1994;91:2216–2220
  11. Cheng S, Fockler C, Barnes WM, Higuchi R. Effective amplification of long targets from cloned inserts and human genomic DNA. PNAS. Jun 1994;91:5695–5699
  12. Azimifar, S. Babak. Seyedna, S. Yoosef, Zeinali, Sirous. Allele frequencies of three factor VIII gene polymorphisms in Iranian population and their application in hemophilia A carrier detection. Am J Hematol (in press).

PII: S0049-3848(05)00424-X

doi: 10.1016/j.thromres.2005.10.007

Thrombosis Research
Volume 118, Issue 4 , Pages 505-507 , 2006

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