Thrombosis Research
Volume 118, Issue 4 , Pages 501-504 , 2006

Dietary related plasma vitamin C concentration has no effect on anticoagulation response to warfarin

  • Hilary Wynne

      Affiliations

    • Schools of Clinical Medical Sciences, Care of the Elderly, Royal Victoria Infirmary, Newcastle upon Tyne, NE2 4HH, United Kingdom
    • Corresponding Author InformationCorresponding author. Tel.: +44 191 233 6161x25397; fax: +44 191 222 5638.
    • ,
  • Tayyaba Khan

      Affiliations

    • Clinical and Laboratory Sciences, University of Newcastle upon Tyne, United Kingdom
    • ,
  • Peter Avery

      Affiliations

    • Mathematics and Statistics, University of Newcastle upon Tyne, United Kingdom
    • ,
  • Peter Wood

      Affiliations

    • Clinical and Laboratory Sciences, University of Newcastle upon Tyne, United Kingdom
    • ,
  • Alan Ward

      Affiliations

    • Clinical and Laboratory Sciences, University of Newcastle upon Tyne, United Kingdom
    • ,
  • Farhad Kamali

      Affiliations

    • Clinical and Laboratory Sciences, University of Newcastle upon Tyne, United Kingdom

Received 28 April 2005 ,Revised 7 July 2005 ,Accepted 28 July 2005.

References 

  1. Kamali F, Khan TI, King BP, Frearson R, Kesteven P, Wood P, et al. Contribution of age, body size, and CYP2C9 genotype to anticoagulant response to warfarin.. Clin Pharm Ther. 2004;75:204–212
  2. Rost S, Fregin A, Ivaskevicius V. Mutations in VKORCI cause warfarin resistance and multiple coagulation factor deficiencies type 2. Nature. 2004;427:537–541
  3. Kamali F, Edwards C, Butler TJ, Wynne HA. The influence of (R)- and (S)-warfarin, vitamin K and vitamin K epoxide upon warfarin anticoagulation. Thromb Haemost. 2000;84:39–42
  4. Sigell LT, Flessa HC. Drug interactions with anticoagulants. JAMA. 1970;214:2035
  5. Rosenthal G. Interactions of ascorbic acid and warfarin. JAMA. 1971;215:1671
  6. Smith EC, Skalski RJ, Johnson GC, Rossi GV. Interaction of ascorbic acid and warfarin. JAMA. 1972;221:1166
  7. Hume R, Johnstone JMS, Weyers E. Interaction of ascorbic acid and warfarin. JAMA. 1972;219:1479
  8. Khan T, Wynne H, Wood P, Torrance A, Hankey C, Avery P, et al. Dietary vitamin K influences intra-individual variability in anticoagulant response to warfarin. Br J Haematol. 2004;124:348–354
  9. Naidong W, Lee JW. Development and validation of a high performance liquid chromatographic method for the quantitation of warfarin enantiomers in human plasma. J Pharm Biomed Anal. 1993;11:785–792
  10. Davidson KW, Sadowski JA. Determination of vitamin K compounds in plasma or serum by high performance liquid chromatrography using post column chemical reduction and fluorimetric detection. Methods Enzymol. 1997;282:408–421
  11. Lykkesfeldt J. Determination of ascorbic acid and dehydroascorbic acid in biological samples by high performance liquid chromatography using subtraction methods: reliable reduction with tris[2-carboxyethyl]phosphine hydrochloride. Anal Biochem. 2000;282(89):89–93
  12. DuBois D, DuBois EF. A formula to estimate the approximate surface area if height and weight be known. Arch Int Med. 1916;17:863–867
  13. Rowland M, Tozer TN. Multiple dose regimens. In:  Rowland M,  Tozer TN editor. Clinical pharmacokinetics, concepts and implications. 3rd ed.. Baltimore (MD): Williams and Wilkins; 1995;p. 83–105
  14. Kallner A, Hartmann D, Hornig D. Steady-state turnover and body pool of ascorbic acid in man. Am J Clin Nutr. 1979;32:530–539
  15. Dedichen J. The effect of ascorbic acid given to patients on chronic anticoagulant therapy. Boll Soc Ital Cardiol. 1973;18:690–692
  16. Feetam CL, Leach RH, Meynell MJ. Lack of a clinically important interaction between warfarin and ascorbic acid. Toxicol Appl Pharmacol. 1975;31:544–547
  17. Sullivan WR, Gangstad EO, Link KP. Studies on the hemorrhagic sweet clover disease: XIX. The effect of I-ascorbic acid on the hypoprothromboinaemia induced by 3.31 – methylenebis – (4-hydroxy-coumarin) in the guinea pig. J Biol Chem. 1943;151:477–485
  18. Deckert FW. Ascorbic acid and warfarin. JAMA. 1973;223:440
  19. Weintraub M, Griner PF. Warfarin and ascorbic acid: lack of evidence for a drug interaction. Toxicol Appl Pharmacol. 1974;28:53–56
  20. McCance RA, Widdowson EM. McCance and Widdowson's The Composition of Foods. 5th edn. Royal Society of Chemistry and Ministry of Agriculture, Fisheries and Food, Cambridge, UK; 1991.

PII: S0049-3848(05)00342-7

doi: 10.1016/j.thromres.2005.07.017

Thrombosis Research
Volume 118, Issue 4 , Pages 501-504 , 2006

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